What to Know About Zoloft

An SSRI Approved to Treat Anxiety, Depression, and Panic Disorder

Zoloft (sertraline) is a tablet or liquid antidepressant medication that may be prescribed to treat a number of mental health disorders including depression, premenstrual dysphoric disorder, panic disorder, obsessive-compulsive disorder, and social anxiety disorder.

Zoloft is a selective serotonin reuptake inhibitor (SSRI) that is also sold under the generic name sertraline. SSRIs prevent the reuptake of serotonin, allowing more serotonin to stay in the brain, which may improve your overall mood, sleep, and appetite, while also decreasing compulsive behaviors, symptoms of anxiety, and panic attacks.

How Zoloft Works

Zoloft belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). As an SSRI, Zoloft blocks the reabsorption, or uptake, of serotonin in the brain, leaving more of the chemical available. Serotonin is a neurotransmitter that, among other responsibilities, helps regulate your mood, learning, and memory. In particular, serotonin is associated with positive emotions; in fact, it’s sometimes called the “happy” chemical.

Uses of Zoloft – Buy Zoloft (Sertraline) – Zoloft for sale

Zoloft has been approved by the Food and Drug Administration (FDA) to treat:

Off-Label Uses

Although Zoloft is not specifically FDA-approved to treat these disorders, some mental health providers or doctors may prescribe it off-label for generalized anxiety disorder, bulimia nervosa, premature ejaculation, and binge eating disorder.1 If you are prescribed Zoloft off-label, be sure you feel comfortable with this option, and if not, request alternative treatment options, and/or more information about why your provider is prescribing this particular medication for you.

Before Taking

When prescribing Zoloft, your treating mental health provider and/or doctor may evaluate your mental health symptoms and overall health using:

  • The DSM-5 to give you an official diagnosis
  • A physical evaluation and/or lab tests to rule out underlying health conditions that may be impacting or causing symptoms


Prior to prescribing Zoloft, your doctor will ask you questions about your symptoms, their intensity, and their frequency. They may also give you assessment questionnaires to complete. Depending on your specific needs, you may be prescribed Zoloft while also attending psychotherapy, or sometimes on its own.https://4615cab660690699e2015ec8b4a34130.safeframe.googlesyndication.com/safeframe/1-0-38/html/container.html

Sertraline Vs. Zoloft – buy Zoloft (Sertraline) online

The FDA notes that both generic sertraline and Zoloft have similar efficacy when it comes to treating the mental health disorders for which it’s approved. However, negative perceptions of generic medications and differing non-active ingredients can impact how each drug affects each individual.2

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Talk to your doctor about all medications, supplements, and vitamins that you currently take. While some drugs pose minor interaction risks, others may outright contraindicate use or prompt careful consideration as to whether the pros of treatment outweigh the cons in your case.

Precautions and Contraindications

Prior to taking Zoloft, let your doctor know:

  • If you have an allergy to anything in Zoloft, including the inactive ingredients
  • If you have a history of bleeding problems, seizures, liver problems, heart problems, low sodium blood levels, thyroid disorders, or glaucoma
  • If you have a family history of bipolar disorder
  • If you are taking an additional medication that increases serotonin levels
  • If you are pregnant and which trimester you are in (third trimester is most at risk for complications)
  • If you are nursing

Zoloft is contraindicated for use with monoamine oxidase inhibitors (MAOIs), pimozide, and disulfiram (when taken with liquid Zoloft). It is critical to disclose to your doctor all current and past medications (including allergy medications), your mental health history, as well as your family medical and mental health history to ensure that Zoloft is safe for you.

Populations Most At Risk

Older adults, children diagnosed with mental health disorders other than OCD, those who are pregnant or breastfeeding, and those who are taking diuretics are at greater risk for complications and may not be prescribed Zoloft.

Other SSRIs

Examples of other SSRIs used to treat similar mental health disorders include Prozac (fluoxetine), Paxil (paroxetine), and Lexapro (escitalopram). These medications also work by increasing the amount of serotonin available in the brain.


According to Pfizer, the recommended dosage of Zoloft will vary depending on the mental health disorder.

  • Major depressive disorder: The starting dosage is 50 milligrams (mg) per day with a maximum of 200 mg per day.
  • Obsessive compulsive disorder: The starting dosage is 25 mg per day for those 6 to 12 years old and 50 mg per day for those 13 years old and older, with a maximum dosage of 200 mg per day.
  • Panic disorder: The starting dosage is 25 mg per day with a maximum dosage of 200 mg per day.
  • Social anxiety disorder: The starting dosage is 25 mg per day with a maximum dosage of 200 mg per day.
  • Post traumatic stress disorder: The starting dosage is 25 mg per day with a maximum dosage of 200 mg per day.
  • Premenstrual dysphoric disorder: The starting dosage for intermittent dosing (during the luteal phase only) is 50 mg per day with a maximum 100 mg per day. The starting dosage for continuous dosing (during the entire month) is 50 mg per day with a maximum dosage of 150 mg per day. Zoloft (Sertraline)

Zoloft Dosage

All listed dosages are according to the drug manufacturer. Check your prescription and talk to your doctor to make sure you are taking the right dose for you.


Certain populations may react to Zoloft differently and may require an adjusted dosage, as well as closer monitoring by their healthcare provider.

  • Zoloft is not approved for use by children under the age of 6.
  • The only FDA-approved use for children ages 6 to 17 is OCD, not any other mental health disorder.
  • Children 6 to 17 years old may require closer monitoring and a subsequent dosage change if during the first few months of taking Zoloft they experience significant weight loss and/or suicidal ideation.
  • Pregnant and nursing individuals will need to discuss the risks and benefits of Zoloft with their doctor, as it can pose a greater risk to their fetus and newborn during the third trimester and during breastfeeding.
  • It is recommended that older patients begin with dosages on the lower end to watch for adverse reactions prior to increasing their dosage if needed. Zoloft (Sertraline)

Liquid Zoloft

While many individuals opt to take Zoloft in tablet form, an oral liquid is available. If you have a latex sensitivity or allergy, you may not be able to take the liquid form as the dropper contains a natural rubber. If taking the oral liquid:

  • The solution must be diluted with half a cup of water, ginger ale, lemon aid, lemon-lime soda, or orange juice.
  • The dosage must be taken immediately upon dilution.

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